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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant.

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Surgical site infections (SSIs) after liver transplant (LT) impact outcomes. Prior LT and living donation increase SSI risk, which is linked to graft loss and death.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Surgical site infections (SSIs) are common healthcare-associated infections.
  • SSIs can adversely affect liver transplant (LT) recipients.

Purpose of the Study:

  • To determine the incidence of SSIs post-LT.
  • To identify risk factors for SSIs.
  • To assess the association between SSIs and mortality or graft loss.

Main Methods:

  • Multicenter cohort study of LT recipients in Switzerland (2008-2020).
  • Analysis included 1158 adult LT recipients.
  • SSIs were defined by CDC criteria within 90 days; outcomes assessed at 1 year.

Main Results:

  • 6.0% of patients developed SSIs, predominantly organ-space infections.
  • Prior LT and living liver donation were independent risk factors for SSIs.
  • SSIs were significantly associated with graft loss and/or death (HR 3.24).

Conclusions:

  • Prior LT and living donation are key risk factors for SSIs.
  • SSIs are a significant independent predictor of adverse outcomes, including graft loss and mortality.
  • These findings underscore the importance of managing SSIs in LT recipients.