[Intestinal gluconeogenesis : When the intestine produces glucose to prevent obesity and hepatic steatosis]

Intestinal gluconeogenesis refers to the ability of the gut to produce glucose outside of meals. By initiating a gut-brain neural axis, its activation by dietary fiber or protein improves the regulation of energy balance. Recently, the creation of a genetic activation model of intestinal gluconeogenesis has demonstrated its anti-obesity, anti-diabetes and anti-hepatic steatosis effects. Interestingly, it increases thermogenesis in brown adipose tissue, thereby promoting energy expenditure and contributing to the fight against obesity. Therefore, targeting intestinal gluconeogenesis could be an innovative strategy to address metabolic diseases such as hepatic steatosis and diabetes, paving the way to new therapeutic approaches.