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Updated: May 21, 2025

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
SnapShot: Human sperm-egg interface proteins
Emily Forster1, Xinyin Wang1, Abenan Thayaparan1
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Abstract:
Human fertilization is a complex, highly regulated process that involves intricate molecular interactions between sperm and egg. Ultimately, this process culminates in the fusion of the gamete membranes to form a zygote. Gene disruption studies in mice have identified several critical fertilization factors. This SnapShot highlights the structure function of key proteins at the sperm-egg interface, providing insights into the mechanism of fertilization. To view this SnapShot, open or download the PDF.
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