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Updated: May 21, 2025
00:08
In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells
Published on: September 2, 2019
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Targeting biomolecular condensates: The rise of engineered chaperones
Yevheniia Bushman1, Duhita A Mirikar1, Andrew W Truman1
1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Cell Chemical Biology
|March 21, 2025
Abstract:
Molecular chaperones like Hsp70s are key players in protein quality control (PQC), capable of eliminating toxic intracellular condensates. In this issue of Cell Chemical Biology, Zhang et al.1 present a computational approach to design novel J-domain protein (JDP) constructs that bind to Hsp70 and enhance its chaperone activity.
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