Heterogeneity in benign and malignant salivary gland tumors

Advanced proteomics tools have identified the role of proteins in cancer biology, highlighting the importance of these molecules for biomarker discovery and providing valuable insights into cancer diagnosis, prognosis, and targeted therapy. Proteome analysis of tissue using high-throughput proteomics techniques has identified proteins associated with recurrence and malignant transformation in benign tumors, and protein profiling of fine needle aspiration has revealed potential biomarkers for distinguishing malignant salivary gland tumors from benign ones. In addition, proteomics studies have identified distinct protein expression patterns in mesenchymal stem cells derived from malignant salivary gland tumors, suggesting a potential role for proteins in adverse behavior and/or targeted therapy. To provide a comprehensive knowledge of salivary gland tumors, this review will first provide a brief description of the molecular and cellular alterations in common benign and malignant salivary gland tumors and then describe the proteomics studies by concentration on different biological sources including serum/plasma, saliva, tumor tissues and related derivatives (e.g. mesenchymal stem cells, tumor cells, tumor established cell lines, and fine needle aspiration), and introduce potential targets for diagnosis, prognosis, and cancer therapy.