Molecular mechanisms associated with embryotoxic effects of heavy metals in the Sea Urchin

The sea urchin embryo model has become a classic model for studying the harmful effects of heavy metals and the molecular responses associated with exposure to these pollutants. In this context, several biochemical pathways have been associated with exposure to heavy metals in sea urchin embryos, such as autophagy, apoptosis, oxidative stress, activation of heat shock proteins, and induction of metallothioneins. These biochemical pathways are activated or altered in embryos after exposure to heavy metals; therefore, this review provides a comprehensive literature exploration, summarizing the main biochemical changes observed in sea urchin embryos following exposure to certain heavy metals, such as cadmium, gadolinium, arsenic, manganese, zinc, mercury, copper, nickel, and lead.