Prurigo nodularis phenotype in the bullous dermatoses spectrum

Prurigo nodularis (PN) of Hyde is a highly pruritic condition that results from the vicious cycle of itching and scratching. An increasing number of case studies report PN-mimicking lesions in patients with confirmed autoimmune bullous dermatoses (AIBDs). The PN lesions usually precede the blister formation and thus raise the question about the pathogenic relation between the two conditions and the possible role of PN as a trigger of AIBDs. We shed light on PN in the context of AIBDs, especially regarding the clinical characteristics and pathogenesis of the PN-like phenotype of bullous pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis, as well as in the hereditary bullous dermatoses setting, namely, epidermolysis bullosa pruriginosa.