Related Experiment Video
Updated: May 13, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Unraveling the heterogeneity of asthma: Decoding subtypes of asthma
Anne L Fuhlbrigge1, Sunita Sharma1
1Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colo.
Abstract:
Asthma is a heterogeneous disease with diverse underlying mechanisms contributing to disease susceptibility and progression. Asthma endotypes and phenotypes have emerged as critical frameworks to help understand the variation in disease presentation and response to therapies. Phenotypes are the observable characteristics or traits of an organism that are produced by the interaction of genotype and environment. Asthma endotypes are distinct subsets of asthma that are characterized by specific biologic pathways, including differences in inflammatory pathways, genetic predisposition, and immune response. Identifying asthma endotypes and the associated clinical phenotypes is pivotal for the development of personalized treatment strategies, as it enables clinicians to select more effective therapies based on specific biologic mechanisms. This review explores asthma endotypes and their associated phenotypes and the ongoing effort to refine diagnostic tools and therapeutic personalized approaches, aiming to improve outcomes for patients with asthma.
Related Concept Videos
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma I: Introduction
Asthma III: Clinical Manifestations

