Related Experiment Video
Updated: May 21, 2025
Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
Cardiac arrhythmia in patients with inflammatory bowel disease: a retrospective, population-based cohort study in
Mariam Narous1, Zoann Nugent1, Inna Rabinovich-Nikitin1
1University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada.
Insights
Individuals with inflammatory bowel disease (IBD) face a higher risk of cardiac arrhythmia, even before heart disease diagnosis. Common IBD medications did not increase this arrhythmia risk.
Area of Science:
- Gastroenterology
- Cardiology
- Epidemiology
Background:
- Inflammatory bowel disease (IBD) is linked to various extraintestinal manifestations.
- Cardiac complications in IBD patients require further investigation, particularly arrhythmia risk.
Purpose of the Study:
- To investigate the association between inflammatory bowel disease (IBD) and the risk of developing cardiac arrhythmia.
- To assess the impact of IBD medications on arrhythmia development.
Main Methods:
- A retrospective, population-based cohort study utilized the University of Manitoba IBD Epidemiology Database (1984-2018).
- 10,992 IBD cases were compared with 102,875 matched controls.
- Arrhythmia risk was analyzed, adjusting for comorbidities using the Charlson Comorbidity Index.
Main Results:
- Patients with IBD showed a 1.51-fold increased likelihood of developing arrhythmia compared to controls (HR 1.51; 95% CI, 1.30 to 1.76).
- The association between IBD and arrhythmia remained significant after adjusting for comorbidities.
- No increased arrhythmia risk was observed with the use of 5-aminosalicylates, thiopurines, or tumor necrosis factor-α inhibitors.
Conclusions:
- Individuals with IBD have an elevated risk of cardiac arrhythmia, independent of heart disease diagnosis.
- Standard IBD medications are not associated with an increased risk of cardiac arrhythmia.
Objective:
We aimed to characterise the association between inflammatory bowel disease (IBD) and IBD medications and risk of cardiac arrhythmia.
Design, Setting And Participants:
In a retrospective population-based study using the University of Manitoba IBD Epidemiology Database (Manitoba, Canada) from 1984 to 2018, we identified 10 992 IBD cases and 102 875 matched controls.
Analysis:
Arrhythmia risk in IBD was adjusted for the presence of comorbidities of the Charlson Comorbidity Index. The effect of IBD medications on the development of arrhythmia was assessed in a nested cohort study of individuals with IBD. Cases were censored at the date of first database identification of a diagnosis of heart failure or myocardial infarction.
Results:
The cohort was 48.5% Crohn's disease and 51.5% ulcerative colitis, and 80.5% were incident cases. The median age of incident cases at IBD diagnosis was 35 (IQR, 25 to 49). The median age at arrhythmia diagnosis for persons with IBD was 69 years (IQR, 59 to 77) and for controls 69 years (IQR, 59 to 78). Persons diagnosed with IBD were more likely than controls (HR 1.51; 95% CI, 1.30 to 1.76) to develop arrhythmia. Persons within their sixth decade or younger had increased risk of arrhythmia. When controlling for comorbidities, the significant association between IBD and arrhythmia remains. Medications including 5-aminosalicylates, thiopurines and tumour necrosis factor-α inhibitors were not associated with arrhythmia.
Conclusions:
Persons with IBD have a higher risk of arrhythmia prior to a diagnosis with heart disease. Use of IBD medications was not associated with risk of arrhythmia.
More Related Videos
08:43Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
07:45Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
Published on: September 1, 2017
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:28Mechanism of Cardiac Arrhythmias
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:28Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...