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Intra-arterial lidocaine improves long-term survival in patients with hepatocellular carcinoma undergoing

Fang Yan1, Wanyu Wang2, Zhiwen Yang1

  • 1Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.

British Journal of Anaesthesia
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Intra-arterial lidocaine may improve survival for liver cancer patients undergoing TACE. This local anesthetic shows promise in enhancing progression-free and overall survival in hepatocellular carcinoma (HCC) treatment.

Keywords:
hepatocellular carcinomaintra-arterial lidocaine administrationlong-term survivalpropensity score matchingtranscatheter arterial chemoembolisation

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Area of Science:

  • Oncology
  • Anesthesiology
  • Pharmacology

Background:

  • Lidocaine, a common local anesthetic, exhibits anticancer properties.
  • Previous research suggests lidocaine's potential in cancer treatment.
  • Hepatocellular carcinoma (HCC) is a significant global health concern.

Purpose of the Study:

  • To investigate the impact of intra-arterial lidocaine on long-term survival in HCC patients undergoing transcatheter arterial chemoembolisation (TACE).
  • To evaluate the efficacy of combining intra-arterial lidocaine with platinum-based chemotherapy during TACE.

Main Methods:

  • Retrospective cohort study of HCC patients receiving TACE.
  • Patients were divided into lidocaine and no lidocaine groups.
  • Propensity score matching and subgroup analysis were performed to compare survival outcomes.

Main Results:

  • Intra-arterial lidocaine was associated with significantly longer progression-free survival (PFS) and overall survival.
  • These survival benefits persisted after propensity score matching.
  • Lidocaine was identified as an independent prognostic factor for improved PFS and overall survival.

Conclusions:

  • Intra-arterial lidocaine shows potential to enhance long-term survival in HCC patients undergoing TACE.
  • The combination of lidocaine with platinum-based chemotherapy during TACE may offer survival advantages.
  • This study underscores lidocaine's potential antitumour benefits in cancer therapy.