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JCL Roundtable: Prediabetes

Kevin C Maki1, Carol F Kirkpatrick2, Jaime Almandoz3

  • 1Midwest Biomedical Research, Addison, IL, USA (Drs Maki, Kirkpatrick); Department of Applied Health Science, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA (Dr Maki).

Journal of Clinical Lipidology
|March 21, 2025
PubMed

Insights

Prediabetes impacts over a third of US adults, increasing risks for type 2 diabetes and other serious conditions. Addressing excess adiposity through lifestyle changes and medication is crucial for management and prevention.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Cardiovascular Health

Background:

  • Prediabetes affects over 1 in 3 US adults, significantly raising risks for type 2 diabetes, cardiovascular disease, chronic kidney disease, and dementia.
  • Excess adiposity is the primary risk factor for prediabetes, exacerbating cardiometabolic issues like dyslipidemia and insulin resistance.

Purpose of the Study:

  • To discuss lifestyle and pharmacologic interventions for managing prediabetes.
  • To explore strategies for preventing associated health risks in prediabetic individuals.
  • To emphasize the role of addressing excess adiposity in prediabetes management.

Main Methods:

  • A roundtable discussion format featuring experts in the field.
  • Exploration of various intervention strategies including lifestyle modifications, pharmacotherapy, and metabolic surgery.
  • Focus on patient-centered care and shared decision-making.

Main Results:

  • Interventions targeting excess adiposity are vital for prediabetes management.
  • A combination of lifestyle, pharmacologic, and surgical approaches can be effective.
  • Shared decision-making is key for patient adherence and treatment success.

Conclusions:

  • Effective management of prediabetes requires addressing excess adiposity through comprehensive strategies.
  • Patient involvement in treatment planning enhances the likelihood of successful outcomes.
  • Timely interventions can mitigate the severe health risks associated with prediabetes.

Keywords:
AdiposityAntiobesity medicationsCardiometabolic healthLifestyle interventionsObesityPrediabetes

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