Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

585
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
585
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.3K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

23
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flavorzyme Hydrolyzed Cordyceps militaris Mushroom Enhanced Quality and Functional Properties of Chicken Breast Meat during Storage.

Food science of animal resources·2026
Same author

Standard-dose direct oral anticoagulants for Asian patients with atrial fibrillation: the definitive case from COMBINE AF.

European heart journal·2026
Same author

Prior anticoagulation experience and bleeding risk with the factor XI inhibitor abelacimab in AZALEA-TIMI 71.

Blood·2026
Same author

Sterilization efficacy of a warm-air circulation system in a vaporized hydrogen peroxide sterilizer.

PloS one·2026
Same author

Efficacy and Safety of Fimasartan/Indapamide Combination Therapy versus Fimasartan Monotherapy in Patients with Essential Hypertension Inadequately Responding to Fimasartan 30 mg (FINEDUO): A Randomized, Double-Blind, Multicenter, Phase III Study.

Drug design, development and therapy·2026
Same author

Feasibility and Safety on Left Bundle Branch Area Pacing With Standard Stylet-Driven Lead: ACHIEVE-SYNC Multicenter Prospective Observational Cohort Study.

Journal of arrhythmia·2026

Related Experiment Video

Updated: May 21, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.2K

Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke

Juntae Kim1,2, Dongmin Kim2, Daehoon Kim1

  • 1Division of Cardiology, Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea.

Journal of the American Heart Association
|March 21, 2025
PubMed
Summary
This summary is machine-generated.

Genetic risk for atrial fibrillation (AF) predicts stroke and systemic embolism in patients with low-intermediate stroke risk. This finding aids in stratifying AF patients for cardiovascular events.

Keywords:
atrial fibrillationpolygenic risk scorestroke risk

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.4K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.6K

Related Experiment Videos

Last Updated: May 21, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.2K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.4K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.6K

Area of Science:

  • Cardiology
  • Genetics
  • Bioinformatics

Background:

  • The clinical utility of polygenic risk scores (PRS) for predicting cardiovascular events in atrial fibrillation (AF) patients remains under investigation.
  • Current risk stratification models for AF may not fully capture genetic predispositions to cardiovascular events.

Purpose of the Study:

  • To evaluate the utility of an AF-specific polygenic risk score in stratifying cardiovascular event risk among oral anticoagulation-naive AF patients.
  • To determine if genetic risk influences the occurrence of ischemic stroke, systemic embolism, myocardial infarction, or heart failure hospitalization in AF patients.

Main Methods:

  • A cohort of 9597 oral anticoagulation-naive AF patients with CHA2DS2-VA scores of 0 or 1 from the UK Biobank was analyzed.
  • Patients were stratified into tertiles based on their polygenic risk score.
  • Inverse probability of treatment weighting was used to assess the association between genetic risk and incident cardiovascular events over a median follow-up of 4.6 years.

Main Results:

  • High genetic risk was significantly associated with an increased hazard ratio for ischemic stroke or systemic embolism (HR 1.38, P=0.011) compared to low genetic risk.
  • No significant association was found between high genetic risk and myocardial infarction (HR 1.15, P=0.422) or heart failure hospitalization (HR 1.02, P=0.895).

Conclusions:

  • In atrial fibrillation patients with low-to-intermediate stroke risk, genetic predisposition (polygenic risk score) is linked to an elevated risk of stroke or systemic embolism.
  • Polygenic risk scores may offer value in refining risk stratification for AF-related thromboembolic events.