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Related Experiment Videos

Vena caval filter to prevent pulmonary embolism: experimental study. Work in progress.

R W Günther, H Schild, A Fries

    Radiology
    |August 1, 1985
    PubMed
    Summary

    A novel inferior vena cava filter effectively captures emboli in canine studies. The self-orienting, securely fixed device shows promise for clinical use, with prototype improvements addressing initial leg breakage.

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    Area of Science:

    • Vascular Surgery
    • Biomedical Engineering
    • Medical Device Development

    Background:

    • Inferior vena cava (IVC) filters are crucial for preventing pulmonary embolism.
    • Existing filters may have limitations in deployment, fixation, or patency.
    • A new filter design aims to improve safety and efficacy.

    Purpose of the Study:

    • To evaluate the performance and safety of a novel IVC filter prototype.
    • To assess the filter's deployment, fixation, retrieval, and embolic capture capabilities.
    • To identify any adverse events or limitations in an experimental setting.

    Main Methods:

    • In vitro testing and experimental implantation in 23 dogs.
    • Percutaneous insertion and retrieval using standard techniques.

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  • Assessment of filter migration, emboli capture, upstream pressure, and patency.
  • Histopathological examination of the IVC wall.

    • Main Results:

    • The filter demonstrated effective emboli capture of various sizes without significant pressure elevation.
    • Secure self-orientation and fixation in the IVC were observed, with no migration.
    • Short-term follow-up showed minimal spontaneous thrombus formation; long-term follow-up indicated filter patency.
    • Histology revealed intimal sclerosis; initial anchor leg breakage was resolved through prototype modification.

    Conclusions:

    • The novel IVC filter is effective and safe in experimental models.
    • The device's design allows for secure placement and retrieval.
    • Prototype improvements have addressed initial mechanical failures, making it suitable for clinical trials.