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Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Related Experiment Video

Updated: May 21, 2025

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

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Human microbiome acquisition and transmission.

Vitor Heidrich1, Mireia Valles-Colomer2, Nicola Segata3,4,5

  • 1Department CIBIO, University of Trento, Trento, Italy.

Nature Reviews. Microbiology
|March 22, 2025
PubMed
Summary
This summary is machine-generated.

Human microbiomes are acquired and transmitted throughout life via interactions with people and the environment. Understanding these transmission dynamics is crucial for health and disease research.

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Area of Science:

  • Microbiology
  • Human Health
  • Microbiome Research

Background:

  • Personal microbiomes are integral to human biology and health.
  • Microbiomes are not static but are continuously shaped by microbial exchange.
  • Lifelong processes of microbiome acquisition and transmission occur throughout human life.

Purpose of the Study:

  • To review recent studies on human microbiome transmission pathways.
  • To explore methodological approaches for inferring microbiome transmission.
  • To highlight the implications of microbiome transmission for host regulation and disease.

Main Methods:

  • Review of current scientific literature on microbiome transmission.
  • Analysis of studies focusing on microbial strain uniqueness for transmission inference.
  • Examination of data from birth, human-to-human, and environmental interactions.

Main Results:

  • Microbiome acquisition begins at birth and continues through various interactions.
  • Single microbial strains serve as unique markers for tracking transmission.
  • Evidence suggests acquisition from animals and food, necessitating a broader perspective.

Conclusions:

  • Understanding human microbiome transmission is key to advancing microbiome-associated disease research.
  • Effective microbiome-targeting strategies depend on knowledge of transmission dynamics.
  • A One Health perspective is essential for a comprehensive understanding of microbiome acquisition and transmission.