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An in-depth benchmark framework for evaluating single cell RNA-seq dropout imputation methods and the development of

Jinghan Huang1, Anson C M Chow2,3, Nelson L S Tang1,3,4

  • 1Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Clinical and Translational Medicine
|March 22, 2025
PubMed
Summary

No abstract available in PubMed .

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...

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