Sequential and Long-term Therapy for Osteoporosis.
1Founding and Emeritus Director, Oregon Osteoporosis Center, Portland, OR, United States of America. mmcclung.ooc@gmail.com.
Current Osteoporosis Reports
|March 22, 2025
Summary
Effective osteoporosis management requires lifelong strategies. This review discusses therapeutic transitions and proposes intermittent bisphosphonate therapy for sustained osteoporosis treatment and maintenance.
Area of Science:
- Endocrinology
- Pharmacology
- Geriatrics
Background:
- Osteoporosis necessitates lifelong management involving sequential drug therapies and long-term maintenance.
- Understanding drug effects and limitations is crucial for optimizing osteoporosis treatment.
Purpose of the Study:
- To review critical transitions between osteoporosis therapies.
- To outline a strategy for intermittent bisphosphonate therapy in long-term osteoporosis management.
Main Methods:
- Review of extant evidence.
- Analysis of clinical experience.
- Expert opinion synthesis.
Main Results:
- Long-term effects and limitations of bisphosphonates and denosumab are now apparent.
- Key factors for sequential use of anti-remodeling and osteoanabolic agents identified.
- Strategies for drug transitions (estrogen, bisphosphonates, denosumab, bone-forming agents) discussed.
Conclusions:
- Optimizing therapeutic benefits and minimizing safety issues depend on appropriate initial and subsequent drug selection.
- A long-term maintenance strategy ensures sustained benefits from initial osteoporosis therapies.
- Developing a comprehensive life plan is essential for managing patients with osteoporosis.
Keywords:
Bisphosphonate holidayDenosumab discontinuationMaintenance therapyOsteoporosisTreatment sequenceMore Related Videos
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