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In vitro susceptibility studies with josamycin and erythromycin
Antimicrobial Agents and Chemotherapy
|March 1, 1976
Summary
This study compared the in vitro activity of josamycin and erythromycin against bacteria. Erythromycin showed slightly higher activity by weight, but both antibiotics demonstrated a comparable spectrum of action.
Area of Science:
- Microbiology
- Pharmacology
Background:
- Josamycin and erythromycin are macrolide antibiotics.
- Macrolides are used to treat bacterial infections.
Purpose of the Study:
- To compare the in vitro antibacterial activity of josamycin and erythromycin.
- To determine the relative potency and spectrum of activity of these two macrolides.
Main Methods:
- In vitro susceptibility testing was performed.
- Five different bacterial species were used in the comparison.
- Antibacterial activity was assessed by weight.
Main Results:
- Erythromycin exhibited slightly greater activity than josamycin on a weight basis.
- Both josamycin and erythromycin displayed a similar range of antibacterial activity.
- The minimal inhibitory concentrations (MICs) were compared between the two drugs.
Conclusions:
- Josamycin and erythromycin possess comparable in vitro activity against the tested bacterial species.
- Erythromycin may be slightly more potent by weight.
- Both macrolides are effective antibacterial agents within a similar spectrum.