Related Experiment Video
Updated: May 21, 2025

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
Published on: June 2, 2023
Does healthy lifestyle attenuate the associations of phthalates with depression? A cross-sectional study
Yue He1, Yan Xu1, Chengxiang Hu1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun, Jilin 130021, China.
Abstract:
Phthalates have raised concerns on health outcomes including depression, due to its ubiquity. Knowledge is lacking on the role of modifiable lifestyle in attenuating phthalates' adverse effects. We aimed to evaluate the interaction effects of lifestyle with urinary phthalate metabolites (UPMs) on depression. A total of 3588 participants aged ≥ 20 from the National Health and Nutrition Examination Survey 2011-2018 were involved. We used multivariate logistic regression models and Bayesian Kernel Machine Regression models to evaluate the associations of UPMs (individual or mixture) and lifestyle with depression. Positive associations of individual UPMs and its mixture with depression were observed in total population and participants maintaining an unfavorable lifestyle. No such association was found in participants with a healthy lifestyle. Interactions between lifestyle category with MECPP (P for interaction = 0.028), and ΣDEHP (P for interaction = 0.087) on depression were observed. Additionally, smoking, alcohol consumption and physical activity in healthy levels showed the greatest effect against depression among the common lifestyle combinations. In conclusion, positive associations of UPMs with depression risk, and interaction effects of lifestyle and UPMs on depression were observed. Our findings indicate that healthy lifestyle might weaken the adverse effects of phthalate exposure on depression risk.
More Related Videos
Related Concept Videos
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Stress Prevention and Stress Management Techniques IV
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Introduction to Stress and Lifestyle
Hormonal Regulation

