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Mapping Brain-Wide Neural Activity of Murine Attentional Processing in the Five-Choice Serial Reaction Time Task
Yin Yue1, Youming Tan2, Pin Yang3
1The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China. yuey17@tsinghua.org.cn.
Neuroscience Bulletin
|March 23, 2025
Summary
This study reveals brain-wide neural activity during attention, highlighting the thalamus as a key control hub. Understanding these attention networks offers insights into cognitive function.
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- Attention is crucial for processing information.
- Neural activity of attention is well-studied in the cortex, but brain-wide patterns remain unclear.
Purpose of the Study:
- To comprehensively analyze brain-wide neural activity during attentional processing in mice.
- To identify key brain regions and networks involved in attention control.
Main Methods:
- Used electroencephalography (EEG) and c-Fos staining for neural activity analysis.
- Applied hierarchical clustering and functional network analysis to c-Fos activation patterns.
Main Results:
- Identified widespread brain region activation during attention.
- Highlighted high-order cortex, thalamus, and brain stem regions involved in cognition and arousal.
- Found the central lateral nucleus of the thalamus to be a significant hub for attention control.
Conclusions:
- The thalamus plays a critical role in attention control.
- These findings provide insights into neural network mechanisms of attention.
- Results form a basis for future functional hypotheses and circuit-level research.
