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Cognitive behavioral therapy combined with escitalopram in the treatment of senile depression
Aiping Wen1, Zhaohui Wei2, Shuxin Zhang3
1Department of Neurology, Leting County Hospital, Leting, China.
Background:
To explore the effect of cognitive behavioral therapy combined with escitalopram in the treatment of senile depression.
Methods:
A total of 230 elderly patients with depression admitted to our hospital from were selected as the observation objects. The control group (n = 115) was treated with escitalopram, and the observation group (n = 115) was combined with cognitive behavioral therapy on the basis of escitalopram. The levels of serum laboratory indexes (S100 protein, cortisol (Cor), homocysteine (Hcy), 5-hydroxytryptamine (5-HT), dopamine (DA), norepinephrine (NE)), daily living ability, depression status and cognitive function in 2 groups before and after treatment were observed.
Results:
After treatment, the levels of S100 protein, Cor and Hcy in the observation group were significantly lower than those in the control group, while the levels of 5-HT, DA and NE were significantly higher than those in the control group (P < 0.05). After treatment, the Barthel index and Montreal Cognitive Assessment (MoCA) score of the observation group were significantly higher than that of the control group, while the Hamilton Depression Scale (HAMD) was significantly lower than that of the control group (P < 0.05). The treatment efficiency (95.65 %) was significantly higher than that of the control group (85.22 %), and the total incidence of adverse reactions (6.09 %) during the treatment period was significantly lower than that of the control group(17.39 %) (P < 0.05).
Conclusion:
For elderly patients with depression, combined cognitive behavioral therapy based on escitalopram help patients to further improve the ability of daily living, improve depression, and promote the recovery of cognitive function.
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