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Medical SAM adapter: Adapting segment anything model for medical image segmentation
Junde Wu1, Ziyue Wang2, Mingxuan Hong1
1Department of Biomedical Engineering, National University of Singapore, Singapore.
Medical Image Analysis
|March 23, 2025
Summary
The Medical SAM Adapter (Med-SA) enhances the Segment Anything Model (SAM) for medical image segmentation. Med-SA achieves superior performance on 17 tasks by adapting SAM with minimal parameter updates, improving medical AI capabilities.
Area of Science:
- Artificial Intelligence
- Medical Imaging
- Computer Vision
Background:
- The Segment Anything Model (SAM) demonstrates broad applicability in image segmentation.
- SAM exhibits limitations in medical image segmentation due to a lack of domain-specific knowledge.
- Adapting foundation models like SAM for specialized tasks is crucial for advancing AI in medicine.
Purpose of the Study:
- To develop an effective method for adapting SAM to medical image segmentation tasks.
- To enhance SAM's performance in segmenting diverse medical imaging modalities.
- To propose lightweight adaptation techniques that preserve SAM's general capabilities.
Main Methods:
- Introduction of the Medical SAM Adapter (Med-SA), a novel adaptation technique for SAM.
- Utilizing a light adaptation strategy, avoiding full model fine-tuning.
- Development of Space-Depth Transpose (SD-Trans) for 3D medical image adaptation.
- Implementation of Hyper-Prompting Adapter (HyP-Adpt) for prompt-conditioned adaptation.
Main Results:
- Med-SA demonstrated superior performance across 17 diverse medical image segmentation tasks.
- The adaptation process required updating only 2% of SAM's parameters (13 million).
- The proposed methods successfully adapted 2D SAM for 3D medical image analysis.
Conclusions:
- Med-SA offers an efficient and effective solution for enhancing SAM in medical image segmentation.
- Lightweight adaptation techniques can successfully integrate domain-specific knowledge into large foundation models.
- The approach shows significant potential for improving AI-driven diagnostics and analysis in healthcare.

