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Small molecule compounds targeting G9a/GLP: Recent advances and perspectives

Qiangsheng Zhang1, Lu Li2, Siyan Li3

  • 1School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.

European Journal of Medicinal Chemistry
|March 23, 2025
PubMed
Summary

Small molecule inhibitors targeting G9a/GLP, crucial in diseases like cancer, have advanced significantly. This review details their discovery, design, and development, offering insights for pharmaceutical research.

Keywords:
Covalent inhibitorDegraderDual-inhibitorG9aGLP

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