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Lipidomics and cardiovascular disease

Arun Surendran1, Hannah Zhang2, Aleksandra Stamenkovic2

  • 1Mass Spectrometry Core Facility, BRIC-Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|March 23, 2025
PubMed

Insights

Lipidomics, the study of lipids, offers new ways to detect cardiovascular diseases (CVDs) like heart attacks and strokes. Identifying specific lipid biomarkers improves personalized treatment and risk prediction for better heart health.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Lipidomics

Background:

  • Cardiovascular diseases (CVDs) are the leading global cause of death.
  • Early detection and personalized interventions are crucial for managing CVDs.
  • Lipidomics utilizes advanced mass spectrometry to understand lipid roles in CVDs.

Purpose of the Study:

  • To review the application of lipidomics in identifying biomarkers for major CVDs.
  • To explore technological advancements in lipidomics for cardiovascular research.
  • To highlight the integration of lipidomics with other omics data for enhanced CVD understanding.

Main Methods:

  • Review of lipidomics applications in identifying biomarkers for myocardial infarction, heart failure, stroke, and calcific aortic valve stenosis (CAVS).
  • Examination of technological advancements in shotgun lipidomics and liquid chromatography-mass spectrometry (LC/MS).
  • Analysis of integrating lipidomics with genomic and proteomic data.

Main Results:

  • Lipidomics effectively identifies biomarkers for various cardiovascular conditions.
  • Advanced techniques like shotgun lipidomics and LC/MS provide deep insights into lipid profiles.
  • Specific lipids, such as ceramides and lysophospholipids, are linked to disease progression and treatment response.

Conclusions:

  • Lipidomics is a powerful tool for discovering cardiovascular disease biomarkers.
  • Technological progress in lipidomics enhances the understanding of lipid functions in CVDs.
  • Integrating lipidomics with other omics data revolutionizes cardiovascular research and clinical practice.

Keywords:
BiomarkersCardiovascular diseaseLipid metabolismLipidomicsMass spectrometry

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