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Published on: March 11, 2014
Human papillomavirus genotype distribution among high-grade cervical lesions in French women born between 1972 and
Philomène Lenoir1, Julie Guillet2, Maxime Desmarets3
1CHU Besançon, Service de Gynécologie, F-25000 Besançon, France.
Background:
Implementation of HPV vaccination programmes may induce significant changes in the distribution of HPV genotypes detected in cervical (pre-)cancers.
Methods:
In a multicentre study in France, we investigated the distribution of HPV genotypes using a sensitive molecular technique in 611 histological specimens diagnosed with high-grade lesions (CIN2/3) in a large cohort of women born between 1972 and 1993. Women born after 1983 were potentially vaccinated because of their young age.
Results:
High-risk HPV genotypes were detected in 93.4 % of women and 24.4 % had a multiple infections. HPV16/18 genotypes were more frequently associated with CIN3 than with CIN2 lesions (66 % vs. 57 %, p = 0.045). The prevalence of HPV16 and HV18 genotypes did not change according to the year of birth.
Conclusion:
Contrary to previous descriptions in countries with a high HPV vaccination coverage, we did not observe difference in the prevalence of HPV16 and HPV18 genotypes in CIN2/3 lesions after the introduction of HPV vaccination in France, in a context of low national vaccination coverage.
Gov Id:
NCT04167501.
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