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Updated: May 7, 2026

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Asperstrins A-H: Epipolythiodioxopiperazines from the endophytic fungus Aspergillus nidulans
Jiajun Zhang1, Jiaxin Dong1, Aimin Fu1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Abstract:
Eight previously undescribed epipolythiodioxopiperazines (ETPs), asperstrins A-H (1-8), and three known analogues, dethiosecoemestrin (9), secoemestrin C (10), and secoemestrin D (11), were isolated from the endophytic fungus Aspergillus nidulans. Their structures and configurations were elucidated based on HRESIMS, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography. Asperstrins A-C (1-3) represent the first examples of O-methyl or O-ethyl derivatives of emestrin-type ETPs, respectively. Asperstrin C (3) showed moderate cytotoxic activities with IC50 values ranging from 3.00 to 4.60 μM; asperstrins F (6) and G (7) displayed potent butyrylcholinesterase inhibitory activities with IC50 values of 9.49 ± 0.51 and 2.03 ± 0.55 μM, respectively.
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