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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Bioactive secondary metabolites from Dentipellis fragilis with anti-inflammatory and cytotoxic activity
Dae-Cheol Choi1, Yoon Hee Kim2, Min-Ju Park2
1Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan 54596, Republic of Korea.
Abstract:
Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3-6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC50 values.
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