Burden of disease and risk factors for primary liver cancer by etiology in the United States, 1990-2021: Results from the Global Burden of Disease study, 2021
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View abstract on PubMed
Summary
This summary is machine-generated.Liver cancer burden in the US increased from 1990 to 2021, driven by Hepatitis C virus and rapidly growing metabolic dysfunction-associated steatotic liver disease. Targeted strategies are needed.
Area Of Science
- Hepatology and Gastroenterology
- Cancer Epidemiology
- Public Health
Background
- Liver cancer (LC) incidence and causes in the US have undergone significant shifts.
- Understanding these temporal trends is crucial for effective public health interventions.
Purpose Of The Study
- To analyze recent temporal trends in the etiologies of liver cancer in the US from 1990 to 2021.
- To predict future trends in liver cancer burden.
Main Methods
- Utilized data from the Global Burden of Disease (GBD) 2021 study for US liver cancer.
- Employed linear regression to calculate Estimated Annual Percentage Change (EAPC).
- Applied Exponential Smoothing (ES) and Bayesian Age-Period-Cohort (BAPC) models for future projections.
Main Results
- The overall disease burden of liver cancer in the US was substantially higher in 2021 compared to 1990.
- Hepatitis C virus (HCV)-associated liver cancer represented the largest disease burden.
- Metabolic dysfunction-associated steatotic liver disease (MASLD)-associated liver cancer exhibited the fastest-growing burden.
- Higher disease burdens were observed in older individuals and males.
Conclusions
- The disease burden of liver cancer from various etiologies continues to escalate in the US.
- Development of targeted prevention and control strategies is essential to address the specific characteristics of these rising liver cancer burdens.
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