Computational flow dynamics of a novel next-generation flow diverter

Area of Science:

• Biomedical engineering
• Medical device technology
• Endovascular therapy

Background:

• Flow-diverting stents (FDS) are crucial for treating complex intracranial aneurysms.
• FDS function by redirecting blood flow to induce thrombosis and occlusion.
• While effective, current FDS offer opportunities for improved performance.

Purpose of the Study:

• To compare the computational fluid dynamics (CFD) and technical feasibility of the Surpass Elite FDS against the Pipeline Embolization Device with Shield Technology (PED-Shield).
• To evaluate the efficacy of the novel Surpass Elite FDS in diverse in vitro aneurysm models.

Main Methods:

• Assessed three CFD metrics: inflow rate reduction, impact zone reduction, and turnover time.
• Utilized seven patient-specific intracranial aneurysm models (basilar tip, vertebral, MCA, ICA).
• Analyzed pore densities and velocity profiles for a comprehensive comparison.

Main Results:

• Surpass Elite FDS achieved greater inflow rate and impact zone reduction across all models.
• Elite demonstrated improved turnover time compared to PED-Shield.
• Higher pore densities were observed with Elite at proximal, aneurysm, and distal points.

Conclusions:

• The Surpass Elite FDS exhibits superior CFD performance over PED-Shield in all tested in vitro models.
• Elite's higher pore density enhances flow diversion and promotes thrombosis within the aneurysm sac.
• Surpass Elite shows significant potential for improving aneurysm occlusion rates compared to PED-Shield.