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A less detailed job axis in a quantitative job-exposure matrix results in a similar exposure-response association
Johan Ohlander1, Susan Peters2, Hans Kromhout2
1Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands j.p.g.ohlander@uu.nl.
Introduction:
Quantitative job-exposure matrices (JEMs) have been developed to assign exposure using International Standard Classification of Occupations (ISCO)-68 coded job information. For extended compatibility with the less detailed ISCO-88 coding, a quantitative JEM using the same underlying model was developed. We compared exposure-response relationships between cumulative respirable crystalline silica (RCS) and lung cancer risk using a quantitative JEM based on ISCO-88 (88-JEM) and ISCO-68 (68-JEM).
Methods:
Based on a common set of approximately 15 000 RCS measurements, job-specific, region-specific and time-specific exposure levels were estimated for the 88-JEM and the 68-JEM and linked to participants' job histories. Exposure-response relationships in an international lung cancer case-control study were analysed by logistic regression and generalised additive models.
Results:
The 88-JEM and the 68-JEM yielded similar RCS-lung cancer associations, with elevated lung cancer risks across each cumulative exposure quartile. The 88-JEM exhibited a minor not statistically significant upward bend in the exposure-response curve at higher exposures.
Conclusion:
To accurately detect associations between disease risk and occupational exposure, quantitative JEMs can be applied in community-based studies that provide job histories in either ISCO-88 or ISCO-68.
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