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The study of human transfer factor.

Z L Li

    Scientia Sinica. Series B, Chemical, Biological, Agricultural, Medical & Earth Sciences
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Human transfer factor (TF) shows potent immunomodulatory effects. A novel dialysis method accelerates TF preparation, enabling its use in treating immune-compromised patients effectively.

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    Area of Science:

    • Immunology
    • Biochemistry
    • Cell Biology

    Background:

    • Human transfer factor (TF) is a complex molecule involved in cell-mediated immunity.
    • Current methods for TF preparation can be time-consuming and prone to contamination.
    • Assessing TF biological activity requires reliable in vitro methods.

    Purpose of the Study:

    • To report the study of human transfer factor (TF).
    • To establish an improved method for TF preparation.
    • To evaluate TF's biological activity and clinical efficacy.

    Main Methods:

    • A negative pressure dialysis method was developed for crude leukocyte extract treatment.
    • Incubation of human TF with human cord blood T-lymphocytes and pig lymphocytes.
    • Assays included SRBC rosette enhancement and electrophoresis rate measurement.

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  • Clinical trials involving patients with compromised cell-mediated immunity.

    • Main Results:

    • The negative pressure dialysis method yielded dialysate rapidly (5 h), simplifying large-scale preparation and reducing contamination risk.
    • Significant biological activity was observed in SRBC rosette enhancement and electrophoresis rate.
    • TF demonstrated efficacy as an immunopotentiating or immunomodulation agent in clinical trials.

    Conclusions:

    • The novel dialysis method offers an efficient and safe approach to human TF preparation.
    • In vitro assays for SRBC rosette enhancement and electrophoresis rate are valuable for evaluating TF activity.
    • Human TF is an effective agent for modulating immune responses in patients with compromised cell-mediated immunity.