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Surface modified proteins and peptides for targeted drug delivery
1Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.
Progress in Molecular Biology and Translational Science
|March 23, 2025
Summary
Surface modification of proteins and peptides improves therapeutic efficacy and targeting. Strategies like chemical conjugation and mutagenesis enhance drug delivery, stability, and circulation time for novel treatments.
Area of Science:
- Biochemistry and Molecular Biology
- Drug Delivery and Pharmaceutical Sciences
Background:
- Proteins and peptides are crucial therapeutic agents but often face challenges with efficacy and specificity.
- Surface modification offers a powerful approach to overcome these limitations.
Purpose of the Study:
- To explore techniques for modifying protein and peptide surfaces to enhance therapeutic properties.
- To focus on strategies improving drug delivery to specific targets like tumors and inflamed tissues.
Main Methods:
- Chemical conjugation
- Site-specific mutagenesis
- Peptide synthesis
Main Results:
- Surface modification enhances drug stability and reduces immunogenicity.
- Improved circulation time and targeted drug delivery to specific sites.
- Development of novel therapeutic agents through surface-engineered biomolecules.
Conclusions:
- Surface modification is a key strategy for advancing protein and peptide therapeutics.
- This approach holds significant potential for developing next-generation targeted therapies.
Keywords:
BioconjugationBiomaterialsDrug delivery systemsPharmaceutical sciencesProtein and peptide engineeringSurface modificationTargeted drug deliveryMore Related Videos
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