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Depolarizing Blockers: Pharmocokinetics

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...

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Related Experiment Video

Updated: May 20, 2025

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

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Published on: September 24, 2021

Standardizing Protamine Dosage in Cardiac Surgery

¹Western University, Division of Critical Care, Department of Medicine, Department of Anesthesia and Perioperative Medicine, London Health Sciences Centre, London, Ontario, Canada.

Journal of Cardiothoracic and Vascular Anesthesia

|March 23, 2025

Summary

No abstract available in PubMed .

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