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Related Experiment Videos

Selenium in the anterior pituitary.

O Thorlacius-Ussing, G Danscher, B Møller-Madsen

    The Science of the Total Environment
    |March 15, 1985
    PubMed
    Summary

    Selenium accumulates in rat anterior pituitary after sodium selenite injection. It binds to cations, likely zinc, within lysosomes and secretory granules.

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    Area of Science:

    • Endocrinology
    • Toxicology
    • Cell Biology

    Background:

    • The anterior pituitary gland plays a crucial role in hormone regulation.
    • Understanding the distribution and binding of trace elements like selenium is vital for assessing potential toxicity and physiological roles.

    Purpose of the Study:

    • To investigate the accumulation and subcellular localization of selenium in the rat anterior pituitary following administration of sodium selenite.
    • To identify the binding state and cellular compartments of selenium within pituitary cells.

    Main Methods:

    • Rats were administered intraperitoneal injections of sodium selenite (Na2S2O3).
    • Tissue samples from the anterior pituitary were analyzed using electron microscopy for ultrastructural localization.
    • Biochemical analysis was performed to determine the binding state of accumulated selenium.

    Main Results:

    • Significant accumulation of selenium was observed in the anterior pituitary.
    • Selenium was found to be bound to a cation, predominantly identified as zinc (Zn++).
    • Ultrastructural examination revealed selenium localized within lysosomes and secretory granules.

    Conclusions:

    • The anterior pituitary is a target organ for selenium accumulation after sodium selenite exposure.
    • Selenium in the anterior pituitary is associated with zinc and resides in specific cellular organelles, suggesting involvement in cellular processes or detoxification mechanisms.

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