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Copper malabsorption in coeliac disease.

S Jameson, K Hellsing, S Magnusson

    The Science of the Total Environment
    |March 15, 1985
    PubMed
    Summary
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    Patients with proximal intestinal disease show reduced copper uptake. This can lead to copper deficiency anemia, particularly neutropenia, which may improve with a gluten-free diet.

    Area of Science:

    • Gastroenterology
    • Hematology
    • Nutritional Science

    Background:

    • Copper is an essential trace element vital for various physiological processes.
    • Proximal intestinal diseases can potentially impair nutrient absorption.
    • Copper deficiency can manifest with hematological abnormalities.

    Purpose of the Study:

    • To investigate copper absorption in patients with proximal intestinal disease.
    • To explore the link between proximal intestinal disease, copper deficiency, and hematological issues.

    Main Methods:

    • Oral copper sulfate test dose (3 mg Cu++) administered.
    • Copper uptake measured over three hours.
    • Blood counts assessed for abnormalities and response to gluten-free diet.

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    Main Results:

    • Significantly reduced copper uptake observed in patients with proximal intestinal disease compared to controls.
    • Three out of ten patients exhibited unexplained anemia and neutropenia.
    • Hematological parameters normalized in these patients after adopting a gluten-free diet.

    Conclusions:

    • Proximal intestinal disease impairs oral copper absorption.
    • Copper deficiency should be considered in patients with unexplained anemia, especially neutropenia.
    • A gluten-free diet may be beneficial for managing copper deficiency in susceptible individuals.