Capivasertib treatment associated with hypermetabolism of the spleen
Maria Ly1, Gary Z Yu1, Amin Haghighat Jahromi2,3
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract:
Capivasertib has emerged as a promising treatment for advanced breast and prostate cancer. Here, we report two cases of metastatic breast cancer patients who developed splenic hypermetabolism on [18 F]-FDG PET/CT following treatment with capivasertib. To our knowledge, these are the first documented instances of this treatment-related phenomenon. Although the mechanism behind this side effect remains unclear, these cases highlight an important imaging phenomenon that radiologists should consider when interpreting [18 F]-FDG PET/CT scans in patients treated with capivasertib.
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