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Sample Handling

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...

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Comparative analysis of cold-stored platelets using Golden Hour transport boxes: Function and quality.

Jamie Nash¹, Christine Saunders¹, Nicola Pearce¹

¹Component Development and Research Laboratory, Welsh Blood Service, Pontyclun, UK.

|March 24, 2025

Summary

Cold-stored platelets (CSP) maintained in Golden Hour boxes show comparable function to conventionally stored platelets. This method may enable prehospital use of CSP for damage control resuscitation.

Keywords:

air ambulance cold stored platelets platelet storage platelet transfusion prehospital major hemorrhage

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Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

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Published on: January 10, 2025

Area of Science:

Emergency Medicine
Transfusion Medicine
Critical Care

Background:

Prehospital critical care services face challenges storing platelet concentrates (PCs) at 22°C with agitation.
Cold-stored platelets (CSP) at 4°C offer potential for improved hemostasis and longer storage.
Investigating CSP storage in Golden Hour (GH) boxes for prehospital use is crucial.

Purpose of the Study:

To assess the viability of storing CSP in GH boxes for up to 96 hours.
To evaluate the impact of GH box storage on platelet function and viability.
To determine the potential for enhanced prehospital damage control resuscitation.

Main Methods:

PCs were stored as CSP (4°C, no agitation) or GH-CSP (GH box days 2-6, then refrigeration).
In vitro assessments included aggregometry, thrombin generation, thromboelastography, and platelet activation markers (P-selectin, annexin V).
Temperature stability of GH boxes with CSP and red cell concentrates was monitored.

Main Results:

GH boxes maintained 2-6°C for up to 84 hours with CSP and red cells.
Platelet function assays showed no significant differences between CSP and GH-CSP.
GH-CSP exhibited increased annexin V binding on days 8 and 15 compared to CSP.

Conclusions:

CSP stored in GH boxes demonstrated comparable platelet function to conventional CSP.
GH box storage of CSP is a potentially viable method for prehospital applications.
This approach could expand the use of CSP in prehospital damage control resuscitation.