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Updated: May 20, 2025
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Advances in research on gut microbiota and allergic diseases in children
Heng Ke1, Hongbing Yao1, Ping Wei1
1Department of Otolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Insights
Childhood allergic diseases like eczema and asthma are increasing globally. Gut microbiota imbalances are linked to these conditions, suggesting probiotics may help manage pediatric allergies.
Area of Science:
- Pediatric Allergy and Immunology
- Microbiome Research
- Public Health
Background:
- Allergic diseases are a growing global health concern, particularly in children.
- The 'atopic march' describes the typical progression of allergic conditions in childhood.
- Gut microbiota dysbiosis is increasingly implicated in the development of pediatric allergic diseases.
Purpose of the Study:
- To review the relationship between gut microbiota and childhood allergic diseases.
- To explore the role of the gut microbiome in the 'atopic march'.
- To discuss the potential of probiotic interventions for pediatric allergies.
Main Methods:
- Literature review of epidemiological and microbiome studies.
- Analysis of gut microbiota development in healthy children.
- Examination of microbial diversity and composition in allergic disease.
Main Results:
- Gut microbiota dysbiosis is associated with the development of allergic diseases.
- Specific microbial patterns are linked to conditions like eczema, food allergies, and asthma.
- The gut microbiome plays a critical role in immune system development and tolerance.
Conclusions:
- The gut microbiota is a key factor in pediatric allergic disease development.
- Understanding gut microbial dynamics offers potential for allergy prevention and treatment.
- Probiotic interventions show promise for managing childhood allergic diseases.
Abstract:
Epidemiological studies indicate a rising prevalence of allergic diseases, now recognized as a major global public health concern. In children, the progression of these diseases often follows the "atopic march," beginning with eczema, followed by food allergies, allergic rhinitis, and asthma. Recent research has linked gut microbiota dysbiosis to the development of allergic diseases in children. The gut microbiota, a crucial component of human health, plays a vital role in maintaining overall well-being, highlighting its potential in preventing and modifying the course of allergic diseases. This review examines the relationship between childhood allergic diseases and gut microbiota, drawing on the latest evidence. We first elaborated the concepts of allergic diseases and gut microbiota, followed by a discussion of the developmental trajectory of the gut microbiota in healthy children. This review further explored the richness, diversity, and composition of the gut microbiota, as well as specific microbial taxa associated with allergic disease. Lastly, we discussed the current status and future potential of probiotic interventions in managing pediatric allergic diseases.
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