2025 Consensus on the Clinical Pathway of Blood Cholesterol Management in Taiwan

Yi-Heng Li1, Chung-Liang Shih2

  • 1Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan.

PubMed

Insights

Achieving cholesterol targets remains a challenge for atherosclerotic cardiovascular disease (ASCVD) prevention in Taiwan. This clinical pathway aims to improve low-density lipoprotein cholesterol (LDL-C) management and patient outcomes.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Public Health

Background:

  • Elevated low-density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerotic cardiovascular disease (ASCVD).
  • Suboptimal achievement of recommended LDL-C targets necessitates improved management strategies in Taiwan.
  • There is a significant need to enhance lipid control for individuals at risk of or with ASCVD.

Purpose of the Study:

  • To introduce a clinical pathway for optimizing cholesterol management in Taiwan.
  • To improve clinical outcomes for ASCVD patients through effective lipid control.
  • To facilitate the achievement of individualized LDL-C targets and reduce cardiovascular events.

Main Methods:

  • Development of a clinical pathway based on Taiwan lipid guidelines and expert consensus.
  • Proposal of tailored LDL-C targets for varying ASCVD risk levels.
  • Standardization of lipid management and follow-up protocols for patients on lipid-lowering therapy.

Main Results:

  • The pathway provides clear LDL-C targets for different ASCVD risk strata.
  • It standardizes the approach to lipid management and patient monitoring.
  • Aims to optimize lipid-lowering therapy for better patient adherence and efficacy.

Conclusions:

  • The clinical pathway offers a structured approach to enhance LDL-C target attainment in Taiwan.
  • It is designed to improve monitoring and optimization of lipid-lowering therapies.
  • Ultimately, it seeks to reduce the incidence of ASCVD events through better cholesterol management.

Related Concept Videos

Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
620
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
475
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
111
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
484
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
51
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
39