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Patient With Tirzepatide-treated Type 2 Diabetes With Difficult Visualization During Esophagogastroduodenoscopy
Hiroki Dobashi1, Daiki Shioya1, Koji Kikkawa1
1Diabetes Center, Hidaka Hospital, Takasaki, Gunma 370-0001, Japan.
JCEM Case Reports
|March 24, 2025
Summary
Tirzepatide use can cause significant food residue in the stomach, hindering endoscopic procedures. Discontinuing tirzepatide for two months allowed for a successful esophagogastroduodenoscopy in a patient with type 2 diabetes.
Area of Science:
- Gastroenterology
- Endocrinology
Background:
- Tirzepatide, a dual GIP and GLP-1 receptor agonist, effectively manages type 2 diabetes and obesity.
- Gastrointestinal side effects, such as delayed gastric emptying, are known adverse events associated with tirzepatide therapy.
Observation:
- A patient on tirzepatide experienced repeated incomplete esophagogastroduodenoscopies due to substantial food residues.
- Standard endoscopic preparation protocols were insufficient to clear the gastric contents in this patient.
Findings:
- A successful esophagogastroduodenoscopy was achieved after a 2-month discontinuation of tirzepatide.
- This case highlights the impact of tirzepatide on gastric motility and its potential to interfere with upper gastrointestinal procedures.
Implications:
- Tirzepatide treatment may necessitate a temporary pause before elective upper gastrointestinal endoscopic evaluations.
- Further research is warranted to establish clear guidelines for managing patients on tirzepatide undergoing endoscopy.
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