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Association between hs-CRP/HDL with type 2 diabetes mellitus in middle-aged and elderly people: a cross-sectional

Yan Jiang1, Jiali Yu2

  • 1Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China.

Frontiers in Endocrinology
|March 24, 2025
PubMed

Insights

The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio may predict type 2 diabetes mellitus (T2DM) risk. Lower hs-CRP/HDL ratios were associated with a reduced likelihood of developing T2DM in older adults.

Area of Science:

  • Biomarkers
  • Epidemiology
  • Metabolic Diseases

Background:

  • Limited research exists on the high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio in relation to type 2 diabetes mellitus (T2DM).
  • The hs-CRP/HDL ratio shows potential as a biomarker for assessing diabetes risk.

Purpose of the Study:

  • To investigate the association between hs-CRP/HDL ratios and the incidence of T2DM.
  • To evaluate the hs-CRP/HDL ratio as a predictive biomarker for T2DM.

Main Methods:

  • Analysis of data from 9,381 Chinese adults aged 45 and older from the 2011 China Health and Retirement Longitudinal Study (CHARLS).
  • Utilized multivariate logistic regression, subgroup analyses, smooth curve fitting, and threshold effect analysis to assess the hs-CRP/HDL ratio's association with T2DM risk.

Main Results:

  • T2DM prevalence was 16.3% in the study population.
  • Participants with T2DM had a 1.2 times higher mean hs-CRP/HDL ratio compared to those without diabetes.
  • An adjusted odds ratio (OR) of 0.75 (95% CI: 0.64-0.87) indicated a reduced T2DM risk with higher hs-CRP/HDL levels. Significant interactions were observed between hs-CRP/HDL ratios and sex/smoking status.

Conclusions:

  • A strong association exists between the hs-CRP/HDL ratio and T2DM risk.
  • The hs-CRP/HDL ratio may serve as a valuable predictive biomarker for T2DM.
  • Further research is needed to fully elucidate the relationship between hs-CRP/HDL ratios and T2DM incidence.
Abstract

Keywords:
CHARLSHDLHs-CRPinflammatory markerstype 2 diabetes mellitus

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