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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Unilateral Eosinophilic Fasciitis With Hand Involvement: A Case Report.

Christian Matthews1, David Thomas2, Luke Monteagudo2

  • 1Department of Family Medicine and Community Health University of Minnesota Minneapolis Minnesota USA.

Clinical Case Reports
|March 24, 2025
PubMed
Summary

Eosinophilic fasciitis (EF), a rare connective tissue disease, can present unusually. This case highlights asymmetric symptoms and hand involvement, leading to diagnosis and successful treatment with steroids.

Keywords:
Shulman syndromeeosinophilic fasciitisfibrosissystemic sclerosis

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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Area of Science:

  • Rheumatology
  • Dermatology
  • Systemic Connective Tissue Diseases

Background:

  • Eosinophilic fasciitis (EF) is a rare systemic connective tissue disease.
  • It involves chronic inflammation of the muscle fascia and subcutaneous tissue.
  • Pathogenesis remains poorly understood, with diagnosis relying on clinical, imaging, and histological findings.

Purpose of the Study:

  • To report a unique case of eosinophilic fasciitis with an unusual asymmetric presentation and hand involvement.
  • To review classic diagnostic criteria for eosinophilic fasciitis.
  • To discuss the potential to avoid full-thickness skin biopsy in favor of early treatment.

Main Methods:

  • Case report of a 24-year-old male with eosinophilic fasciitis.
  • Diagnosis based on physical examination, laboratory results, and MRI imaging.
  • Treatment involved initial steroid therapy followed by steroid-sparing agents.

Main Results:

  • The patient presented with predominantly asymmetric symptoms and hand involvement.
  • Key diagnostic features included physical exam findings, labs, and MRI.
  • The patient showed improvement with corticosteroid treatment and transitioned to steroid-sparing therapy.

Conclusions:

  • Eosinophilic fasciitis can manifest with atypical presentations, including asymmetry and hand involvement.
  • Early diagnosis and treatment are crucial for managing eosinophilic fasciitis.
  • In select cases, early treatment may be considered without a full-thickness skin biopsy.