Pre-Treatment Serum Prognostic Scores and Survival in Curatively Treated Laryngeal Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Prognostic scores, including lymphocyte-to-monocyte ratio (LMR), help predict survival in laryngeal squamous cell cancer (LSCC). Combining these scores with clinical factors improves outcome prediction for LSCC patients.
Area Of Science
- Oncology
- Head and Neck Cancer Research
- Biomarker Discovery
Background
- Laryngeal squamous cell cancer (LSCC) is a significant head and neck cancer.
- Despite decreasing incidence, LSCC survival rates have stagnated.
- Blood-based prognostic scores (NLR, PLR, LMR, SIII) show promise for predicting LSCC outcomes.
Purpose Of The Study
- To evaluate the association of prognostic scores with survival in LSCC patients.
- To determine if combining prognostic scores with clinicopathological variables enhances survival prediction.
Main Methods
- Retrospective analysis of 473 LSCC patients (2014-2020).
- Assessment of overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS).
- Categorization of patients into high- and low-risk groups based on combined prognostic scores.
Main Results
- Low lymphocyte-to-monocyte ratio (LMR) and high-risk scores correlated with poorer OS, CSS, and RFS.
- Nodal status and disease stage remain critical prognostic indicators.
- Integration of clinicopathological variables and prognostic scores improved survival prediction accuracy.
Conclusions
- Prognostic scores are valuable for predicting LSCC survival.
- Combined use of prognostic scores and clinicopathological factors may optimize patient management.
- Further research is needed to validate these findings.
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