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Related Experiment Video

Updated: May 20, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

Association between Plasma Metabolite Levels and Myopia: A 2-Sample Mendelian Randomization Study.

Xiaohui Jiang¹, Boyue Xu², Qiyuan Li¹

¹Eye Hospital of Wenzhou Medical University at Hangzhou, Hangzhou, China.

Ophthalmology Science

|March 24, 2025

Summary

This study used Mendelian randomization to find causal links between plasma metabolites and myopia. Certain metabolites may protect against myopia, while others increase risk, suggesting new therapeutic targets.

Keywords:

Causal analysis Genome-wide association studies Mendelian randomization Myopia Plasma metabolites

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Last Updated: May 20, 2025

Inducement and Evaluation of a Murine Model of Experimental Myopia

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Published on: January 22, 2019

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

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Published on: April 3, 2016

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

Area of Science:

Ophthalmology
Metabolomics
Genetics

Background:

The role of plasma metabolites in myopia development remains unclear.
Previous research on plasma metabolites and myopia is limited and primarily observational.

Purpose of the Study:

To investigate the potential causal relationship between plasma metabolites and myopia.
To leverage 2-sample Mendelian randomization (MR) for robust causal inference.

Main Methods:

A 2-sample Mendelian randomization (MR) study design was employed.
Analyzed 1091 plasma metabolites and 309 ratios from the Canadian Longitudinal Study on Aging cohort.
Utilized UK Biobank data for myopia summary statistics (37,362 cases, 460,536 controls).
Primary analysis used Inverse Variance Weighting (IVW); secondary analyses included MR-Egger and weighted median.

Main Results:

Elevated levels of 1-arachidonoyl-GPE, linoleoyl-arachidonoyl glycerol [1], and linoleoyl-arachidonoyl-glycerol [2] showed a protective effect against myopia.
Increased risk of myopia was associated with elevated levels of four plasma metabolite ratios, including phosphate to linoleoyl-arachidonoyl-glycerol [2] and citrulline to dimethylarginine.

Conclusions:

Established a causal link between specific plasma metabolites and myopia.
Identified potential therapeutic targets for myopia intervention.
Emphasized the need for diverse population studies to generalize findings.