Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional...

Area of Science:

• Immunology
• Pediatric Medicine
• Clinical Management

Background:

• Patients with immune dysregulation present with complex, multisystem conditions including autoimmunity, autoinflammation, and immunodeficiency.
• Diagnosing and treating these patients is challenging due to varied symptoms and complex testing requirements.
• Multidisciplinary teams (MDTs) are increasingly formed to standardize care for immune dysregulation (immMDTs).

Purpose of the Study:

• To provide guidance on the structure and function of pediatric immune dysregulation multidisciplinary teams (immMDTs).
• To summarize best practices and context-dependent solutions for establishing and optimizing immMDTs.
• To address the lack of published information on immMDT composition and function.

Main Methods:

• Convened a panel of 24 pediatric providers actively participating in immMDTs for expert opinion.
• Conducted a literature search on pediatric immMDTs using PubMed.
• Synthesized expert insights and literature findings to inform the review.

Main Results:

• Summarizes the structure and function of active immMDTs across the United States.
• Identifies best practices and context-dependent solutions for immMDT implementation.
• Provides a framework for institutions to establish or optimize their immMDTs based on varying resources and goals.

Conclusions:

• Immune dysregulation multidisciplinary teams (immMDTs) are vital for standardizing evaluation and optimizing treatment for complex cases.
• This review offers practical insights and adaptable strategies for developing effective immMDTs.
• Guidance is provided to help institutions build or enhance immMDTs to meet diverse institutional needs.