Related Experiment Video
Updated: Aug 8, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Bilateral peripheral ulcerative keratitis in a child with juvenile idiopathic arthritis
Alma Siddiqui1, Reena Kumari1, Dinesh Kumar Bhagat1
1Department of Ophthalmology, Mata Gujri Memorial Medical College and L.S.K. Hospital, Kishanganj, Bihar, India.
Insights
Peripheral ulcerative keratitis (PUK) is a serious eye condition causing corneal thinning, often linked to autoimmune diseases. Early diagnosis in children is crucial, as highlighted by a case of bilateral PUK in a 13-year-old girl with juvenile idiopathic arthritis.
Area of Science:
- Ophthalmology
- Rheumatology
- Pediatrics
Background:
- Peripheral ulcerative keratitis (PUK) is an inflammatory eye condition causing corneal thinning and potential vision loss.
- It is frequently associated with systemic autoimmune disorders and typically affects middle-aged females.
Observation:
- A unique case of a 13-year-old female presenting with bilateral PUK is described.
- The patient was later diagnosed with juvenile idiopathic arthritis.
Findings:
- The case highlights the importance of recognizing PUK's ocular manifestations in younger individuals.
- Bilateral PUK in a pediatric patient was successfully managed with systemic methotrexate and topical cyclosporine.
Implications:
- This case underscores the need for heightened awareness of PUK in pediatric autoimmune conditions.
- Prompt diagnosis and multidisciplinary management are vital for preserving vision in affected children.
Abstract:
Peripheral ulcerative keratitis (PUK) is characterized by epithelial destructive lesions in the perilimbal cornea causing corneal thinning. It is an inflammatory condition commonly associated with systemic autoimmune disorders and mainly found in middle-aged females. It is a sight threatening entity with potential for severe visual impairment or loss of eye. Recognition of ocular manifestations of PUK is essential especially in the younger age group, as it is difficult to diagnose in a child. We present a unique case of a 13-year-old girl with bilateral PUK and later diagnosed with juvenile idiopathic arthritis. She was started on methotrexate tablets to control the systemic disease and advised continuation of topical cyclosporine eye drops.
Related Concept Videos
Sex Linked Disorders
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Oppositional Defiant Disorder
Diagnostic Criteria and...
Staphylococcal Skin Infections
Acne Infection

