Related Experiment Video
Updated: May 20, 2025

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
Published on: June 25, 2013
The Impact of Interscalene Brachial Plexus Block with Different Concentrations of Ropivacaine on Diaphragmatic
Ying Deng1,2, Liwei Wang1,2, Hua Zhang3
1Department of Anesthesiology, Peking University Third Hospital, Beijing, People's Republic of China.
Background:
This study aims to evaluate the degree of diaphragmatic paralysis by assessing diaphragmatic excursion and pulmonary function following an ultrasound-guided interscalene brachial plexus block with two different concentrations of ropivacaine (0.2% and 0.5%).
Methods:
Forty patients undergoing shoulder arthroscopic surgery were randomly assigned to receive ultrasound-guided interscalene brachial plexus block with 20 mL of either 0.2% or 0.5% ropivacaine. Diaphragmatic excursion (DE) and diaphragm thickening fraction (TF) were measured using M-mode ultrasound before and 30 minutes after the block. Pulmonary function was assessed using a portable spirometer. Additional outcomes included pain scores and the occurrence of adverse effects.
Results:
DE was significantly reduced 30 minutes after block in the 0.5% group compared to the 0.2% group (p<0.01), as well as the TF (p<0.01). Forced vital capacity (FVC) was also significantly reduced in the 0.5% group 30 minutes after block in the preparation room compared to the 0.2% group (p<0.001). Both 0.2% and 0.5% ropivacaine had similar effects in improving postoperative pain. There were no serious block-related complications in either group.
Conclusion:
0.2% ropivacaine may impair pulmonary function less than 0.5% ropivacaine. The clinical significance of these differences requires further investigation.
More Related Videos
Related Concept Videos
Depolarizing Blockers: Pharmocokinetics
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Depolarizing Blockers: Mechanism of Action
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Skeletal Muscle Relaxants: Therapeutic Uses

