Related Experiment Video
Updated: May 20, 2025
08:58
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.2K
Growing Concerns on Antimicrobial Resistance - Past, Present, and Future Trends
Deepak Saxena1, Richa Gwalani1, Aarti Yadav1
1Department of Public Health, Indian Institute of Public Health, Gandhinagar, Gujarat, India.
Summary
Antimicrobial resistance (AMR) is a growing global crisis, causing 700,000 deaths annually and threatening 10 million by 2050. Understanding AMR
Area of Science:
- Global Health
- Microbiology
- Epidemiology
Background:
- Antimicrobial resistance (AMR) is a significant global threat impacting healthcare, agriculture, and aquaculture.
- AMR claims 700,000 lives yearly, with projections of 10 million deaths by 2050 without intervention.
- Low and middle-income countries (LMICs) face a disproportionately higher burden due to various barriers.
Purpose of the Study:
- To conduct a comprehensive analysis of past, present, and future trends in AMR.
- To explore the interconnected factors contributing to AMR emergence and transmission.
- To provide a holistic perspective on the evolution of AMR.
Main Methods:
- Review of historical trends in antibiotic discovery and resistance.
- Analysis of the current state of AMR, particularly in India.
- Examination of global and country-level policies and innovative approaches.
Main Results:
- Historical analysis reveals patterns in resistance gene evolution and multidrug-resistant pathogens.
- Current trends highlight the severe impact of AMR on clinical medicine and healthcare systems, especially in India.
- Identification of key drivers for the global surge in AMR.
Conclusions:
- Urgent action is needed to halt the spread of AMR.
- Innovative strategies, including alternative therapies and stewardship programs, are crucial for combating resistance.
- A comprehensive understanding of AMR's evolution is essential for effective mitigation.
Keywords:
AMR future threatAMR in Indiaantimicrobial resistanceglobal healthhealth system factors for AMRone healthpublic concernstrategies to mitigate AMRMore Related Videos
06:54Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
Published on: July 19, 2024
925
09:59Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
1.1K
Related Concept Videos
00:57Antibiotic Selection
52.1K
Overview
52.1K
00:46Genomic DNA in Prokaryotes
43.2K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.2K
01:33Bacterial Transformation
55.0K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.0K
01:23Antimicrobial Proteins
841
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
841
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:27Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K