Beta-blocker toxicity--the role of glucagon. Report of 2 cases

We describe 2 cases of acute overdosage with beta-adrenergic receptor blocking agents. Both patients presented with profound bradycardia and cardiogenic shock. The effectiveness of intravenous glucagon administration is demonstrated in the first case. We suggest that glucagon should be used more readily in cases of circulatory failure due to beta-blocker poisoning than has hitherto been the case.