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Updated: Jun 27, 2026

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Obesity-Associated Hyperuricemia in Female Mice: A Reevaluation.

Andrew P Giromini¹, Sonia R Salvatore², Brooke A Maxwell³

¹West Virginia University Departments of Biochemistry and Molecular Medicine, Morgantown, WV, USA.

Gout, Urate, and Crystal Deposition Disease

|March 24, 2025

Summary

This summary is machine-generated.

Obesity increases uric acid (UA) levels in both male and female mice, a condition known as hyperuricemia. This study confirms hyperuricemia is a shared metabolic response to obesogenic diets in both sexes.

Keywords:

diet-induced obesity female mice hyperuricemia impaired glucose tolerance uric acid xanthine oxidoreductase

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Last Updated: Jun 27, 2026

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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

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Published on: March 5, 2022

Area of Science:

Metabolic research
Obesity studies
Cardiovascular health

Background:

Obesity is linked to high uric acid (hyperuricemia), but studies often exclude females, leaving their response undefined.
Hyperuricemia contributes to comorbidities like cardiovascular dysfunction, kidney disease, and NAFLD.
Understanding sex differences in obesity-related metabolic changes is crucial.

Purpose of the Study:

To investigate sex-specific responses to diet-induced obesity (DIO) in mice.
To determine if females develop hyperuricemia under obesogenic conditions.
To compare metabolic profiles of male and female mice on high-fat diets.

Main Methods:

C57BL/6J mice (male and female) were fed either an obesogenic (60% fat) or control (10% fat) diet for 19 weeks.
Phenotypic and metabolic parameters, including weight, glucose tolerance, and circulating uric acid, were measured.
A precise control diet was used for females to ensure accurate comparisons.

Main Results:

Male mice showed significant weight gain, elevated fasting glucose, impaired glucose tolerance, and high uric acid (2.54 mg/dL).
Female mice also developed elevated fasting glucose and impaired glucose tolerance.
Obese female mice exhibited significantly elevated uric acid (2.55 mg/dL) compared to controls (1.68 mg/dL).

Conclusions:

Elevated circulating uric acid is a consistent long-term response to obesogenic diets in both male and female mice.
This finding aligns with clinical observations of hyperuricemia in obesity across both sexes.
Accurate control diet selection is critical for reliable research conclusions.