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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Malignancy-associated risk factors in patients with systemic sclerosis
Serdar Baysal1, Didem Şahin2, Serdar Sezer2
1Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
Journal of Scleroderma and Related Disorders
|March 24, 2025
Summary
Systemic sclerosis increases cancer risk, with lung cancer being most common. Advanced age at diagnosis is a key risk factor, suggesting enhanced cancer screenings for these patients.
Area of Science:
- Rheumatology
- Oncology
- Epidemiology
Background:
- Systemic sclerosis (SSc) is linked to elevated cancer incidence.
- Understanding specific malignancies and risk factors in SSc is crucial for patient management.
Purpose of the Study:
- To identify common cancers in systemic sclerosis patients.
- To determine factors associated with increased cancer risk in this population.
Main Methods:
- A single-center, retrospective study.
- Analysis of 252 systemic sclerosis patients' medical records from January 2005 to December 2021.
Main Results:
- Nineteen out of 252 patients developed malignancies.
- Lung cancer was the most frequent malignancy.
- Advanced age at SSc diagnosis significantly increased malignancy risk (p=0.017).
- No correlation found with sex, follow-up, SSc type, organ involvement, smoking, serology, comorbidities, or DMARDs.
Conclusions:
- Advanced age at systemic sclerosis diagnosis is an independent risk factor for cancer.
- Consideration of enhanced cancer screening in older SSc patients is warranted.
- Commonly used disease-modifying antirheumatic drugs (DMARDs) like methotrexate, cyclophosphamide, azathioprine, and mycophenolate mofetil do not appear to increase cancer risk.
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